IRS4 CLIA Kit for Human(Homo sapiens) | EIAab.comIRS4 CLIA Kit for Human(Homo sapiens)

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IRS4 (Gene name),

Insulin receptor substrate 4 (Protein name ), IRS4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IRS4;

Protein name:

Insulin receptor substrate 4(IRS-4);

Alternative:

Phosphoprotein of 160 kDa(pp160);160 kDa phosphotyrosine protein(py160);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1 (By similarity). Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with GRB2 and PIK3R1. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH.

Function:

Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.

Subcellular Location:

Cell membrane Peripheral membrane protein Cytoplasmic side

Protein Attributes:

Sequence length:

1257

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

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750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1257:

DSPKRGR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:8471

SMR:

O14654

String:

O14654

STRING:

9606.ENSP00000361202

MIM:

603510

UniGene:

Hs.460872

Pfam:

PF02174

MIM:

300904

Uniprot:

O14654

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ELISA Kit for Human IRS-4

Cat.:

E0288m

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Packing:

96T

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ELISA Kit for Human IRS-4

Cat.:

E0288h

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Manual:

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Packing:

96T

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CLIA Kit for Human IRS-4

Cat.:

U0288m

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MSDS:

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Packing:

96T

CLIA Kit for Human IRS-4

Cat.:

U0288h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human IRS-4

Cat.:

P0288Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IRS-4

Cat.:

P0288Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IRS-4

Protein for Human IRS-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family."
Lavan B.E. , Fantin V.R. , Chang E.T. , Lane W.S. , Keller S.R. , Lienhard G.E.
J. Biol. Chem.272:21403-21407(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 100-117; 233-240; 613-618; 836-843 AND 844-852;PHOSPHORYLATION
tissue: Kidney.
2.

"The DNA sequence of the human X chromosome."
Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells."
Fantin V.R. , Sparling J.D. , Slot J.W. , Keller S.R. , Lienhard G.E. , Lavan B.E.
J. Biol. Chem.273:10726-10732(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH GRB2 AND PIK3R1;PHOSPHORYLATION
5.

"Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction."
Koval A.P. , Karas M. , Zick Y. , LeRoith D.
J. Biol. Chem.273:14780-14787(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRK AND CRKL
6.

"Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation."
Qu B.-H. , Karas M. , Koval A. , LeRoith D.
J. Biol. Chem.274:31179-31184(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis."
Uchida T. , Myers M.G. Jr. , White M.F.
Mol. Cell. Biol.20:126-138(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GRB2 AND PIK3R1
8.

"The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II."
Karas M. , Koval A.P. , Zick Y. , LeRoith D.
Endocrinology142:1835-1840(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRK;MUTAGENESIS OF TYR-700; TYR-717; TYR-743 AND TYR-779
9.

"Insulin receptor substrate 4 associates with the protein IRAS."
Sano H. , Liu S.C.H. , Lane W.S. , Piletz J.E. , Lienhard G.E.
J. Biol. Chem.277:19439-19447(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NISCH
10.

"Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor."
Schreyer S. , Ledwig D. , Rakatzi I. , Kloeting I. , Eckel J.
Endocrinology144:1211-1218(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
11.

"Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4."
Hinsby A.M. , Olsen J.V. , Mann M.
J. Biol. Chem.279:46438-46447(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-921;INTERACTION WITH SHC1; GRB2; PHOSPHOLIPASE C-GAMMA AND PHOSPHATIDYLINOSITOL 3-KINASE;IDENTIFICATION BY MASS SPECTROMETRY
12.

"Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation."
Mihindukulasuriya K.A. , Zhou G. , Qin J. , Tan T.-H.
J. Biol. Chem.279:46588-46594(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP4C;INDUCTION;IDENTIFICATION BY MASS SPECTROMETRY
13.

"Interaction between Brk kinase and insulin receptor substrate-4."
Qiu H. , Zappacosta F. , Su W. , Annan R.S. , Miller W.T.
Oncogene24:5656-5664(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTK6;IDENTIFICATION BY MASS SPECTROMETRY
14.

"Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation."
Cuevas E.P. , Escribano O. , Chiloeches A. , Ramirez Rubio S. , Roman I.D. , Fernandez-Moreno M.D. , Guijarro L.G.
J. Hepatol.46:1089-1098(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
15.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-20; GLU-215 AND ARG-557

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